TABLE 3

Association between GIP haplotypes and GIP response after glucose challenge tests in 123 pregnant Han-Chinese women

GenotypesPatients (N [%])GIP (pg/mL)Glucose (mg/dL)>140* (%)OR (95% CI)PInsulin (mU/L)C-peptide (ng/mL)Age (years)BMI (kg/m2)
GIP−1920G/G + GIP−1920G/A70 (0.569)85.39 ± 5.41118.0 ± 3.320.035.57 ± 3.185.13 ± 0.2831.6 ± 0.525.4 ± 0.4
GIP−1920A/A53 (0.431)70.87 ± 3.83125.1 ± 3.434.02.06 (0.98–4.65)0.08144.36 ± 5.165.35 ± 0.3830.1 ± 0.726.3 ± 0.7
Total123 (1.000)79.13 ± 3.54121.2 ± 2.526.039.38 ± 2.885.22 ± 0.2331.0 ± 0.425.7 ± 0.4
GIPR1159C/C8 (0.065)65.92 ± 9.13126.0 ± 8.237.530.84 ± 8.055.60 ± 0.8633.0 ± 2.025.9 ± 1.2
GIPR1159C/G43 (0.350)79.93 ± 6.64120.0 ± 4.014.035.77 ± 4.195.36 ± 0.3532.3 ± 0.726.1 ± 0.6
GIPR1159G/G72 (0.585)80.12 ± 4.47121.3 ± 3.331.942.49 ± 4.145.10 ± 0.3230.2 ± 0.525.5 ± 0.5
Total123 (1.000)79.13 ± 3.54121.2 ± 2.526.039.38 ± 2.885.22 ± 0.2331.0 ± 0.425.7 ± 0.4
GIP−1920G/G + IP−1920G/A43 (0.597)86.98 ± 6.57115.2 ± 4.220.935.91 ± 3.914.74 ± 0.3631.4 ± 0.625.1 ± 0.6
GIP−1920A/A29 (0.403)69.95 ± 4.86130.2 ± 5.048.33.53 (1.25–9.92)0.01552.70 ± 8.415.66 ± 0.5928.4 ± 0.925.7 ± 0.8
Total72 (1.000)80.12 ± 4.47121.3 ± 3.231.942.49 ± 4.145.11 ± 0.3230.2 ± 0.525.3 ± 0.5
  • GIP, glucose-dependent insulinotropic polypeptide; OR, odds ratio.

  • *Measured as mg/dL serum glucose level.

  • †Significantly different from patients with a GIP−1920G haplotype (χ2 test, P < 0.05).