TABLE 1

Physiologic overview of SGLT2−/− mice

Body weightBody fatKidney weightPlasma BUNPlasma creatinineUrine outputGlucosuria
Mouse(g)(%)(mg/g)(mg/dL)(mg/dL)(mL/day)(mg/day)
WT29.4 ± 0.76.9 ± 0.76.55 ± 0.4223.2 ± 0.30.074 ± 0.0011.5 ± 0.30.9 ± 0.3
SGLT2−/−26.7 ± 0.6*7.4 ± 0.36.49 ± 0.1423.8 ± 1.10.077 ± 0.0076.7 ± 0.4502 ± 30
HFD/WT35.0 ± 0.726.4 ± 1.2ND20.8 ± 0.70.103 ± 0.0051.7 ± 0.21.0 ± 0.3
HFD/SGLT2−/−33.0 ± 1.022.3 ± 1.9ND18.8 ± 0.70.119 ± 0.0075.4 ± 0.5431 ± 31
  • Data were collected from 16-week-old, ad libitum fed mice. Kidney weight represents the weight of one kidney corrected by body weight. Mice were housed in custom cages for 24 h for urine output and glucosuria measurements. HFD was fed for 4 weeks. n = 12–16 per genotype for body weight and fat data; n = 6–8 for remaining data.

  • *P < 0.05;

  • P < 0.001 for comparison of WT with SGLT2−/− for each diet.

  • Data analyzed by Student t test.

  • ND, not done.