TABLE 2

Hyperinsulinemic euglycemic clamp studies

MousePlasma glucose(mg/dL)Glucose infusion rate(mg · kg−1 · min−1)Endogenous glucose production(mg · kg−1 · min−1)Whole-body glucose uptake(mg · kg−1 · min−1)Skeletal muscle glucose uptake(nmol · g−1 · min−1)White adipose glucose uptake(nmol · g−1 · min−1)Insulin(μU/mL)
db/db
 SGLT2+/+149 ± 132.9 ± 0.821.3 ± 1.224.1 ± 0.9135 ± 2224.7 ± 1.81211 ± 138
 SGLT2+/−152 ± 183.9 ± 1.219.3 ± 1.923.3 ± 1.2134 ± 1827.1 ± 2.21178 ± 105
 SGLT2−/−139 ± 88.0 ± 0.8*16.2 ± 2.124.2 ± 1.9109 ± 1825.2 ± 3.41268 ± 158
  • Whole-body and tissue-specific glucose metabolism during hyperinsulinemic infusion. The db/db-SGLT2+/+ (n = 9), db/db-SGLT2+/− (n = 8), and db/db-SGLT2−/− (n = 7). Data analyzed by Student t test.

  • *P < 0.01;

  • P < 0.05 compared with db/db-SGLT2+/+.