TABLE 1

Data collected at 39 weeks

ZDF fa/+ (lean)ZDF fa/fa (diabetic)
UntreatedMetforminInsulin
n6446
Body weight (g)496.17 ± 13.48403 ± 4.97457 ± 61.52631 ± 36.14*
Food intake (g/day)13.98 ± 3.1139.81 ± 2.50*33.63 ± 9.25*22.38 ± 3.79*
Fed glucose (mg/dL)132.17 ± 15.33573.50 ± 19.50*451.00 ± 116.55*296.33 ± 100.76*
HbA1c (%)3.43 ± 0.2710.38 ± 0.59*7.88 ± 1.27*5.73 ± 1.15*
Urine volume (mL/day)8.55 ± 2.44148.73 ± 11.61*85.48 ± 48.77*32.92 ± 14.07
Urinary albumin (mg ⋅ kg−1 ⋅ day−1)6.85 ± 3.48349.44 ± 92.55*203.80 ± 121.32*§108.51 ± 45.69*
HIF-α immunoreactivity0.0 ± 0.02.0 ± 1.16*0.5 ± 0.58§1.17 ± 0.41
Tubular injury0.0 ± 0.03.0 ± 0.0*1.75 ± 0.96*2.5 ± 0.55*
  • Data are means ± SD unless otherwise indicated.

  • *P < 0.01 vs. lean rats.

  • P < 0.01 vs. untreated diabetic rats.

  • P < 0.01 vs. metformin-treated rats.

  • §P < 0.05;

  • P < 0.05;

  • P < 0.05.