TABLE 1

Type 2 diabetes risk loci genotyped in DPP participants

Genetic locusSNP typedAlleles (risk/other)StrandOR*StudyOverall study (all ethnic groups)
A = risk allele/a = other allele
AAAaaa
N (%)N (%)N (%)
TCF7L2rs7903146T/C+1.37DIAGRAM287 (9.6)1,227 (41.1)1,469 (49.3)
CDKN2A/2Brs10811661T/C+1.26DIAGRAM2,245 (75.3)664 (22.3)71 (2.4)
CDKAL1rs7754840C/G+1.25DIAGRAM453 (15.2)1,348 (45.2)1,180 (39.6)
PPARGrs1801282C/G+1.18DIAGRAM2,501 (83.6)476 (15.9)16 (0.5)
HHEXrs1111875C/T1.17DIAGRAM1,218 (40.8)1,337 (44.8)432 (14.5)
IGF2BP2rs1470579C/A+1.17DIAGRAM598 (20.2)1,185 (40.1)1,175 (39.7)
KCNJ11rs5219T/C+1.16DIAGRAM318 (10.6)1,242 (41.6)1,426 (47.8)
SLC30A8rs13266634C/T+1.15DIAGRAM1,723 (57.7)1,072 (35.9)191 (6.4)
THADArs7578597A/G1.15DIAGRAM2,259 (77.7)587 (20.2)63 (2.2)
CENTD2rs1552224A/C1.14DIAGRAM+2,363 (81.9)494 (17.1)29 (1.0)
NOTCH2rs10923931T/G+1.13DIAGRAM95 (3.3)697 (24.0)2,118 (72.8)
ADCY5rs11708067A/G+1.12MAGIC1,891 (65.7)863 (30.0)125 (4.3)
WFS1rs10010131G/A+1.11DIAGRAM1,315 (44.0)1,302 (43.6)371 (12.4)
CDC123rs4747969C/T+1.11DIAGRAM136 (4.7)959 (33.0)1,814 (62.4)
IRS1rs7578326A/G+1.11DIAGRAM+1,299 (47.1)1,119 (40.6)340 (12.3)
CHCHD9rs13292136C/T+1.11DIAGRAM+2,431 (85.5)389 (13.7)25 (0.9)
JAZF1rs864745G/A+1.10DIAGRAM493 (17.0)1,348 (46.5)1,059 (36.5)
HNF1Brs757210T/C1.10DIAGRAM517 (17.9)1,318 (45.7)1,049 (36.4)
HMGA2rs1531343C/G+1.10DIAGRAM+114 (4.1)692 (24.8)1,987 (71.1)
ADAMTS9rs4607103C/T+1.09DIAGRAM1,478 (50.8)1,201 (41.3)230 (7.9)
TSPAN8rs7961581C/T+1.09DIAGRAM217 (7.5)1,089 (37.4)1,603 (55.1)
MTNR1Brs10830963G/C+1.09MAGIC200 (6.9)998 (34.5)1,692 (58.6)
BCL11Ars243021A/G1.08DIAGRAM+704 (24.4)1,392 (48.3)787 (27.3)
SLC22A18ASrs231362G/A1.08DIAGRAM+1,150 (40.3)1,274 (44.7)427 (15.0)
ZBED3rs4457053G/A+1.08DIAGRAM+251 (8.8)1,148 (40.3)1,447 (50.8)
PROX1rs340874C/T1.07MAGIC630 (22.1)1,305 (45.7)921 (32.3)
GCKrs917793T/A1.07MAGIC168 (5.8)1,015 (35.1)1,707 (59.1)
TSGA13rs972283G/A+1.07DIAGRAM+1,099 (38.8)1,274 (45.0)460 (16.2)
VPS33Brs8042680A/C+1.07DIAGRAM+978 (34.4)1,086 (38.2)783 (27.5)
HNF1Ars7957197T/A+1.07DIAGRAM+2,009 (70.3)756 (26.5)92 (3.2)
DGKBrs2191349T/G+1.06MAGIC870 (30.1)1,401 (48.5)618 (21.4)
GCKRrs780094C/T1.06MAGIC1,258 (43.5)1,281 (44.3)351 (12.2)
PLEKHF2rs896854T/C1.06DIAGRAM+826 (29.0)1,379 (48.4)644 (22.6)
BCL2A1rs11634397G/A+1.06DIAGRAM+988 (34.3)1,348 (46.7)548 (19.0)
  • OR, odds ratio.

  • *OR reported by previous literature (column study).