TABLE 2

Baseline characteristics of DPP participants in each quartile of GRS

Quartile of weighted GRS
Baseline characteristic1st2nd3rd4thP*
Weighted genetic score32 (24–34) N = 71036 (34–37) N = 71138 (37–40) N = 71142 (40–51) N = 711
Female sex (%)460 (64.8)484 (68.1)486 (68.4)482 (67.8)0.049
Self-reported ethnicity
 White (%)481 (67.7)444 (62.4)375 (52.7)295 (41.5)<0.001
 African American (%)41 (5.8)77 (10.8)166 (23.3)295 (41.5)
 Hispanic (%)121 (17.0)121 (17.0)130 (18.3)94 (13.2)
 Asian/Pacific Islander (%)41 (5.8)47 (6.6)19 (2.7)16 (2.3)
 American Indian (%)26 (3.7)22 (3.1)21 (3.0)11 (1.5)
Self-reported family history of DM (%)477 (67.4)483 (67.9)491 (69.1)529 (74.4)<0.001
Age (years)50 (28–85)50 (26–84)50 (25–84)49 (26–83)<0.001
BMI (kg/m2)33 (23–66)33 (23–58)33 (23–65)32 (22–71)0.06
Waist (cm)105 (69–182)104 (70–190)104 (73–159)102 (74–155)<0.001
Fasting plasma glucose (mg/dL)105 (89–136)105 (85–139)106 (82–139)106 (90–138)<0.001
2-h plasma glucose (mg/dL)162 (140–199)165 (140–199)162 (140–199)162 (140–199)0.38
Hypertension (%)165 (23.2)161 (22.6)167 (23.5)154 (21.7)0.90
HDL (mg/dL)43 (21–91)43 (22–105)44 (20–103)45 (19–101)0.002
Fasting triglycerides (mg/dL)152 (37–823)151 (30–695)136 (39–835)125 (36–920)<0.001
ALT18 (3–106)17 (1–112)17 (2–114)17 (1–114)<0.001
CRP (mg/L)0.38 (0.01–12.60)0.38 (0.01–7.36)0.38 (0.01–11.80)0.36 (0.01–11.11)0.83
  • Data are n (%) or median (minimum to maximum) unless otherwise indicated. ALT, alanine transaminase; CRP, C-reactive protein; DM, diabetes.

  • *P value for F tests from general linear models.