TABLE 3

Associations between GRS and insulin secretion or insulin sensitivity indices adjusted for age, sex, ethnic background, and waist circumference in DPP participants

Quartile of weighted GRSβ* (SE)P
1st2nd3rd4th
N710711711711
Weighted genetic score32 (24–34)36 (34–37)38 (37–40)42 (40–51)
Insulinogenic index1.24 (1.17–1.32)1.25 (1.18–1.33)1.25 (1.17–1.32)1.12 (1.05–1.20)−0.004 (0.001)<0.001
ISI (= 1/HOMA-IR)0.157 (0.150–0.164)0.157 (0.150–0.164)0.159 (0.152–0.166)0.161 (0.154–0.169)0.006 (0.002)0.02
Proinsulin-to-insulin ratio0.178 (0.170–0.186)0.181 (0.173–0.189)0.184 (0.176–0.192)0.191 (0.182–0.200)0.008 (0.002)0.001
Disposition index (oral)0.048 (0.046–0.051)0.050 (0.047–0.053)0.050 (0.047–0.053)0.046 (0.043–0.049)−0.004 (0.002)0.06
  • Data are least squares mean (95% CI) unless otherwise indicated. P values for β in the regression model. HOMA-IR, homeostasis model assessment of insulin resistance.

  • *Regression model, per unit increase in GRS.