TABLE 4

Multivariable models to predict progression to diabetes in DPP participants

Minimally adjusted for treatment armsMultiadjusted model
VariablesHR (95% CI)PHR (95% CI)P
Weighted GRS (per risk allele)1.02 (1.00–1.04)0.081.02 (1.00–1.05)0.03
Metformin (vs. placebo)0.71 (0.59–0.86)0.00050.70 (0.58–0.85)0.0003
Lifestyle (vs. placebo)0.46 (0.37–0.57)<0.00010.45 (0.36–0.56)<0.0001
Female (vs. male)0.99 (0.83–1.19)0.94
African American (vs. white)1.03 (0.82–1.29)0.81
Hispanic (vs. white)1.12 (0.88–1.42)0.37
Asian/Pacific Islander (vs. white)1.56 (1.04–2.33)0.03
American Indian (vs. white)0.90 (0.53–1.54)0.70
Age at randomization (per year)1.00 (1.00–1.01)0.45
Waist circumference (per cm)1.02 (1.02–1.03)<0.0001