TABLE 1

Univariate and multivariate analyses of umbilical cord CpG methylation in relation to child’s adiposity measured by DEXA at age 9 years

eNOS chr7:150315553+ (%)PRXRA chr9:136355885+ (%)PSex (%)PVariance explained (%)
Total fat mass (ln kg)
 Univariate analysis210.001210.003390.001
 Multivariate analysis190.002230.001470.00144
Percentage fat (ln %)
 Univariate analysis130.006140.00642<0.001
 Multivariate analysis110.009140.00548<0.00147
Ratio trunk to limb fat (ln)
 Univariate analysis70.00870.016120.009
 Multivariate analysis80.00470.021110.05928
  • Values are the percent change in outcome variable per SD change in CpG methylation and P value. Univariate analysis rows show the regression coefficients and P values relating each of eNOS chr7:150315553+, RXRA chr9:136355885+, and sex to outcomes individually, whereas multivariate analysis rows show regression coefficients and P values for a combined analysis of eNOS chr7:150315553+, RXRA chr9:136355885+, and sex in relation to outcomes, together with the variance explained by the multivariate model. For variances explained, n = 55.