Changes in OGTT-derived measures of β-cell function (insulinogenic index) and insulin sensitivity (1/fasting insulin) for the full cohort from baseline to 0.5 years and rates of change among means from 0.5 to 4 years based on a longitudinal model adjusted for baseline factors
| Variable | Rosiglitazone | Metformin | Glyburide | P value | |
|---|---|---|---|---|---|
| Rosiglitazone vs. metformin | Rosiglitazone vs. glyburide | ||||
| Insulinogenic index (pmol/L per mmol/L) | |||||
| n | 1,125 | 1,124 | 1,060 | — | — |
| Mean %change from 0 to 0.5 years | 0.0 (−3.9, 4.1) | 2.5 (−1.5, 6.7) | 6.6 (2.3, 11.1) | 0.3826 | 0.0249 |
| Rate of change from 0.5 to 4 years (% per year) | −6.0 (−7.2, −4.8) | −7.4 (−8.5, −6.2) | −11.1 (−12.3, −9.8) | 0.1133 | <0.0001 |
| Unweighted mean slope (% per year) | −8.0 (−9.5, −6.4) | −8.8 (−10.3, −7.2) | −13.2 (−15.0, −11.4) | 0.4798 | <0.0001 |
| 1/Fasting insulin (pmol/L−1 × 10−3) | |||||
| n | 1,255 | 1,256 | 1,187 | — | — |
| Mean %change from 0 to 0.5 years | 25.7 (22.8, 28.7) | 13.5 (10.9, 16.2) | −9.2 (−11.4, −7.0) | <0.0001 | <0.0001 |
| Rate of change from 0.5 to 4 years (% per year) | 6.5 (5.8, 7.2) | 5.9 (5.2, 6.7) | 5.5 (4.7, 6.3) | 0.2898 | 0.0822 |
| Unweighted mean slope (% per year) | 6.9 (6.1, 7.8) | 5.3 (4.4, 6.3) | 5.2 (4.1, 6.2) | 0.0176 | 0.0128 |
For the log-transformed insulinogenic index and reciprocal fasting insulin, results are presented as a percentage change from baseline and mean rates of change (percent per year) ± 95% confidence limits. The unweighted mean rate of change (mean slopes) over 0.5 to 4 years are also listed. Changes from baseline, or rates of change, for which the 95% confidence limits do not bracket zero are statistically significantly different at the 0.05 level, without adjustment for multiple tests of significance.