TABLE 1

Circulating lipid and hormone concentrations

FFAs (mM)Triglycerides (mg/dL)Adiponectin (μg/mL)Leptin (ng/mL)
Pairfeeding studies
 Wt RF saline0.6 ± 0.1 (14)21.3 ± 3.0 (21)6.4 ± 1.0 (9)0.8 ± 0.2 (8)
 Wt RF leptin0.6 ± 0.1c (11)15.9 ± 2.8b,c (21)6.4 ± 0.6c (10)1.2 ± 0.2 (6)
 ob/ob RF saline0.9 ± 0.2a (11)30.8 ± 4.7 (11)8.7 ± 0.9 (11)ND (6)
 ob/ob RF leptin0.7 ± 0.1c (11)20.9 ± 2.2c (16)6.9 ± 0.8c (11)1.4 ± 0.3 (5)
 ob/ob CR saline1.1 ± 0.2a (8)41.4 ± 5.3a (10)17.4 ± 1.3a,b (15)ND (5)
db/db CR studies
 Wt RF0.7 ± 0.1 (8)21.3 ± 2.7 (13)5.6 ± 0.8 (6)0.8 ± 0.4 (7)
 db/db RF1.5 ± 0.1a (4)42.6 ± 10.7a (7)8.9 ± 0.6 (7)63.8 ± 1.1a (4)
 db/db CR1.4 ± 0.1a (6)34.6 ± 2. (11)14.6 ± 1.8a,b (10)17.6 ± 1.2a,b (4)
  • Circulating concentrations of FFAs, triglycerides, adiponectin, and leptin were measured after 6 h of fasting (number of animals is indicated in parentheses).

  • aP < 0.05 vs. wt RF saline;

  • bP < 0.05 vs. ob/ob RF saline or db/db RF;

  • cP < 0.05 vs. ob/ob CR saline. ND, not detected; RF, random fed; wt, wild type.