TABLE 2

Heart weights in caloric-restricted ob/ob and db/db mice with leptin treatment

Treatment groupDHW (mg)Tibia length (mm)DHW/Tibia length (mg/mm)
Wt RF saline (25)20.4 ± 0.715.6 ± 0.11.3 ± 4.3 E-05
Wt RF leptin (22)18.1 ± 0.9a,b15.6 ± 0.1b1.2 ± 5.4 E-05a,b
ob/ob RF saline (19)25.1 ± 0.7a14.7 ± 0.1a1.7 ± 4.2 E-05a
ob/ob RF leptin (21)21.4 ± 0.6b15.6 ± 0.1b1.4 ± 3.5 E-05b
ob/ob CR saline (28)19.4 ± 0.6b14.5 ± 0.2a1.3 ± 3.7 E-05b
Wt RF (6)22.4 ± 0.616.7 ± 0.21.4 ± 0.05
db/db RF (8)23.3 ± 0.915.2 ± 0.2a1.5 ± 0.08
db/db CR (8)19.0 ± 0.4a,b14.7 ± 0.2a,b1.3 ± 0.02b
  • Dry heart weights (DHW) obtained after working heart perfusions in 9-week-old male mice with 1 week of intraperitoneal or intracerebroventricular leptin are shown.

  • aP < 0.05 vs. wt RF saline;

  • bP < 0.05 vs. ob/ob RF saline or db/db RF. RF, random fed; wt, wild type.