TABLE 1

Effect of PEDF on muscle lipids in Wt and ATGL−/− mice

Lipid typeWtATGL−/−
VehiclePEDFVehiclePEDF
Triacylglycerol202,356 ± 50,05472,565 ± 8,131*243,282 ± 17,744210,888 ± 52,728
Diacylglycerol53,860 ± 4,52142,232 ± 2,30475,273 ± 26,72754,336 ± 24,595
Phosphatidylglycerol1,597 ± 1812,052 ± 771,789 ± 751,873 ± 101
Phosphatidylinositol20,493 ± 4,13422,446 ± 2,59421,346 ± 2,27320,742 ± 1,775
Phosphatidylethanolamine34,203 ± 3,80340,704 ± 1,19337,618 ± 95238,991 ± 1,299
Phosphatidylserine8,156 ± 4637,630 ± 4138,749 ± 9927,744 ± 385
Cholesterol ester3,738 ± 1,3484,606 ± 1,0084,670 ± 1,1133,928 ± 620
Sphingomyelin261,548 ± 3,995305,516 ± 15,202355,098 ± 22,736320,042 ± 14,868
Ceramide1,924 ± 1231,850 ± 1111,874 ± 1471,809 ± 60
Dihydroceramide253 ± 18372 ± 75302 ± 35266 ± 44
Dihexosylceramide205 ± 45209 ± 42250 ± 24208 ± 24
Monohexosylceramide797 ± 118635 ± 96893 ± 216624 ± 57
GM3 ganglioside152 ± 7120 ± 12135 ± 13156 ± 13
Lysophosphatidylcholine5,212 ± 1,8973,110 ± 3032,907 ± 3203,135 ± 277
  • Units are expressed as pmol/μmol phosphatidylcholine. Wt, Wt + PEDF, ATGL−/− n = 4; ATGL−/− + PEDF n = 8. Values are mean ± SD.

  • *P < 0.05 vs. ATGL−/− PEDF.

  • P < 0.05 vs. vehicle of the same genotype.