TABLE 4

Metabolic characteristics of men and women during OGTT and euglycemic-hyperinsulinemic clamp according to the quartiles of ALT

MenWomen
Q 1Q 2Q 3Q 4P for trendQ1Q2Q3Q4P for trend
Fasting insulinemia (pmol ⋅ L−1)24.0 (15.0)27.0 (17.0)33.0 (23.0)41.4 (29.0)<0.000124.0 (18.0)23.0 (16.0)25.0 (19.0)30.0 (23.0)0.45
Adiponectin (mg/L)6.3 (3.4)6.4 (3.8)6.0 (3.1)5.5 (2.6)0.149.4 (4.7)10.0 (5.2)9.2 (5.0)8.8 (5.4)0.83
M/I (μmol ⋅ min−1 ⋅ kg FFM−1 ⋅ [nmol ⋅ L−1]−1)133.6 (83.3)110.8 (64.1)109.9 (58.1)90.4 (65.3)0.003146.4 (98.6)160.2 (72.3)138.2 (73.7)134.7 (75.5)0.002
Basal insulin secretion rate (pmol/min per m2)61.2 (29.1)71.1 (35.0)75.6 (45.3)94.4 (44.0)<0.000160.6 (31.6)67.0 (31.1)65.6 (33.5)76.6 (42.6)0.0008
Total insulin secretion during OGTT (nmol/m2)35.1 (14.4)38.0 (16.1)43.0 (18.9)45.8 (18.8)<0.000138.1 (15.9)37.8 (14.7)40.9 (15.5)41.8 (18.3)0.08
Endogenous clearance of insulin during OGTT (L/min per m2)1.63 (0.6)1.63 (0.7)1.57 (0.7)1.37 (0.7)0.831.57 (0.7)1.74 (0.6)1.63 (0.7)1.56 (0.8)0.67
Hepatic insulin extraction during OGTT (dimensionless)0.61 (0.2)0.63 (0.1)0.63 (0.2)0.56 (0.2)0.490.62 (0.2)0.63 (0.1)0.62 (0.2)0.62 (0.2)0.17
  • Data are median (interquartile range) unless otherwise indicated. P values are given after adjustment for age, center, physical activity, alcohol intake, and waist circumference. Quartiles of ALT are as follows: men, 3–17, 18–22, 23–29, and >29 IU ⋅ L−1; and women, 2–11, 12–14, 15–19, and >19 IU ⋅ L−1.