TABLE 1

Counterregulatory hormone and insulin values during the euglycemic and hypoglycemic clamps

Time after start of glucose infusion (min)P
Baseline3090120
Glucagon (pmol/L)
 Euglycemic clamp35.5 ± 6.930.5 ± 7.228.4 ± 7.341.4 ± 11.1
 Hypoglycemic clamp27.6 ± 5.141.9 ± 19.853.6 ± 16.477.0 ± 41.90.0080
Adrenaline (nmol/L)
 Euglycemic clamp0.22 ± 0.090.24 ± 0.080.42 ± 0.200.41 ± 0.12
 Hypoglycemic clamp0.20 ± 0.100.82 ± 1.223.96 ± 2.104.84 ± 2.51<0.0001
Noradrenaline (nmol/L)
 Euglycemic clamp0.91 ± 0.220.97 ± 0.211.07 ± 0.261.14 ± 0.31
 Hypoglycemic clamp0.94 ± 0.41.15 ± 0.391.98 ± 1.061.96 ± 0.640.0316
Cortisol (μmol/L)
 Euglycemic clamp0.44 ± 0.290.53 ± 0.130.42 ± 0.150.42 ± 0.13
 Hypoglycemic clamp0.47 ± 0.180.47 ± 0.170.64 ± 0.330.89 ± 0.210.0048
Growth hormone (mU/L)
 Euglycemic clamp5.91 ± 7.456.14 ± 7.8414.86 ± 14.4319.30 ± 18.34
 Hypoglycemic clamp6.17 ± 7.1614.44 ± 33.1946.38 ± 47.9674.09 ± 55.550.0462
Insulin (pmol/L)
 Euglycemic clamp76.6 ± 44.1777.8 ± 190.7685.9 ± 114.9694.1 ± 114.9
 Hypoglycemic clamp63.4 ± 29.5943.7 ± 548.11493.7 ± 349.3685.8 ± 107.10.6824
  • Data are means ± SD. Statistical tests performed with two-way ANOVA.