TABLE 2

Metabolic and physiological parameters of diabetic and control mice treated with either the CB2 agonist (AM1241) or vehicle

NDND+AM1241DMDM+AM1241
Body weight (g)28.80 ± 0.6127.23 ± 0.4324.92 ± 0.33*24.83 ± 0.93*
BG (mg/dL)114 ± 5.44111 ± 5.14326 ± 16.41323 ± 41.10
Glycated Hb (%)4.18 ± 0.354.00 ± 0.1512.79 ± 0.3512.18 ± 1.10
sBP (mmHg)125 ± 6.83119 ± 2.43133 ± 3.16132 ± 5.14
KW/BW ratio5.81 ± 0.036.12 ± 0.087.25 ± 0.296.83 ± 0.30
AER (μg/18 h)78.8 (73.8–86.6)71.9 (69.5–79.6)315.4 (291.9–356.6)162.9 (139.5–161.7)§
  • Data are shown as means ± SEM or geometric means (25th–75th percentile). BG, blood glucose; sBP, systolic blood pressure; KW/BW, kidney weight/body weight; AER, albumin excretion rate.

  • *P < 0.01 DM and DM+AM1241 vs. ND and ND+AM1241.

  • P < 0.001 DM and DM+AM1241 vs. ND and ND+AM1241.

  • P < 0.05 DM and DM+AM1241 vs. ND.

  • §P < 0.001 DM+AM1241 vs. DM.