TABLE 2

Association of proinsulin loci with insulin-processing traits

SNPNearest geneAlleles proinsulin-raising/other32,33-split proinsulin (n = 4,103–6,343)Fasting insulin (n = 36,775–38,335)HOMA-B (n = 35,046–36,606)Insulinogenic index (n = 10,902–14,956)C-peptide (n = 1,537–2,956)
βP valueβP valueβP valueβP valueβP value
rs11603334ARAP1A/G0.1461.2 × 10−250.0120.020.0161.4 × 10−40.0491.1 × 10−50.0170.22
rs10501320MADDG/C0.1241.4 × 10−20−0.0030.45−0.0158.1 × 10−5−0.0050.67−3.0 × 10−40.98
rs6235PCSK1G/C0.0574.5 × 10−60.0010.780.0080.02−0.0040.70−0.0080.46
rs7903146TCF7L2T/C0.0421.5 × 10−3−0.0120.005−0.0201.4 × 10−7−0.0639.6 × 10−70.0000.98
rs4502156VPS13C/C2CD4A/BT/C0.0394.5 × 10−4−0.0020.67−0.0100.004−0.0533.5 × 10−9−0.0170.11
rs11558471SLC30A8A/G0.0591.1 × 10−5−0.0050.21−0.0171.4 × 10−6−0.0320.0010.0030.81
rs10838687MADD (2nd signal)T/G0.0060.710.0060.220.0070.060.00290.79−0.00840.47
rs1549318LARP6T/C0.0431.2 × 10−40.0090.020.0090.007−0.0010.88−0.0140.18
rs4790333SGSM2T/C0.0403.2 × 10−40.0080.040.0020.550.0090.33−0.0150.15
  • β-Coefficients are adjusted for age, sex, and study-specific covariates (if applicable).