TABLE 1

Plasma metabolic parameters of WT and Nrf2-KO mice fed an SD or HFD for 180 days

SDHFD
WTNrf2-KOWTNrf2-KO
Glucose (mg/dL)90 ± 7.288 ± 7.7185.2 ± 12.3143 ± 13.5*
Cholesterol (mg/dL)91.2 ± 8.489 ± 8.8206.6 ± 17.2162.9 ± 22.82
HDL cholesterol (mg/dL)71.3 ± 5.768.7 ± 5.9154.2 ± 7.9107.1 ± 15.8
Triglycerides (mg/dL)59.3 ± 6.871.3 ± 7.981.4 ± 10.05119.3 ± 6.2
Insulin (ng/mL)0.9 ± 0.120.7 ± 0.181.5 ± 0.160.9 ± 0.3
Leptin (pg/mL)4,128 ± 4183,896 ± 40224,830 ± 2,310.417,770 ± 1,620.1*
Free fatty acid (mmol/L)NANA0.331 ± 0.020.336 ± 0.04
β-Hydroxybutyrate (mmol/L)NANA1.439 ± 0.141.483 ± 0.14
FGF21 (pg/mL)492 ± 50488 ± 614,472 ± 626.49,518 ± 817.8
  • Data are means ± SEM. n = 8. Mice were fast overnight before plasma collection. NA, not available.

  • *P < 0.05.

  • P < 0.005.

  • P < 0.0001 (WT vs. Nrf2-KO).