TABLE 3

Association of proinsulin loci with other glycemic traits

SNPNearest geneAlleles proinsulin-raising/otherFasting glucose (n = 44,601–46,186)HOMA-IR (n = 35,512–37,072)Matsuda index (n = 7,055–9,561)2-h glucose (n = 15,088–15,252)2-h insulin (n = 6,923–7,083)HbA1c (n = 33,736–44,731)T2D (n = 8,130 case subjects/38,987 control subjects)BMI (n = 123,260–123,865)
rs11603334ARAP1A/Gβ/OR−0.0190.016−0.0140.009−0.050−0.0230.880.012
P value1.7 × 10−40.1050.2260.0430.2940.0167.8 × 10−60.065
rs10501320MADDG/Cβ/OR0.025−0.0150.009−0.001−0.0120.0041.010.014
P value3.1 × 10−90.7750.4130.6050.4590.5950.6290.012
rs6235PCSK1G/Cβ/OR−0.0140.001−0.0080.0340.0150.0131.020.016
P value4.8 × 10−40.8370.4350.1090.2730.0530.4010.002
rs7903146TCF7L2T/Cβ/OR0.023−0.0100.0140.1080.0040.0151.40−0.019
P value2.8 × 10−80.0340.2444.3 × 10−70.7720.0292.2 × 10−512.4 × 10−4
rs4502156VPS13C/C2CD4A/BT/Cβ/OR0.0200.002−0.004−0.0710.0120.0021.07−0.003
P value8.4 × 10−80.6480.6582.1 × 10−40.3210.7790.0010.528
rs11558471SLC30A8A/Gβ/OR0.027−0.0170.014−0.0020.0800.0131.14−0.012
P value2.6 × 10−110.7140.1971.4 × 10−40.2750.0803.3 × 10−80.027
rs10838687MADD (2nd signal)T/Gβ/OR−0.0110.004−0.0060.0140.003−0.0010.98−0.013
P value0.0140.3830.5780.5120.8300.8760.3830.020
rs1549318LARP6T/Cβ/OR−0.0020.0090.0010.008−0.010−0.0051.010.003
P value0.6980.0440.9060.6210.5560.4440.6670.583
rs4790333SGSM2T/Cβ/OR0.0040.0090.009−0.00020.008−0.0051.01−0.005
P value0.3280.0230.3380.9920.5190.4250.6260.261
  • β-Coefficients are adjusted for age, sex, and study-specific covariates (if applicable). OR is for T2D only as a dichotomous trait.