TABLE 1

Changes in MAP and FBF in protocol 1 experiments

Basal30 min60 min90 min120 min
MAP (mmHg)
 Insulin106 ± 3107 ± 5107 ± 2108 ± 3108 ± 2
 Insulin + PD12331996 ± 592 ± 693 ± 4104 ± 696 ± 6
 Insulin + losartan107 ± 3100 ± 497 ± 7106 ± 5101 ± 5
FBF (mL/min)
 Insulin0.78 ± 0.060.78 ± 0.050.82 ± 0.040.84 ± 0.070.94 ± 0.07*
 Insulin + PD1233190.75 ± 0.040.80 ± 0.040.85 ± 0.090.73 ± 0.060.73 ± 0.07
 Insulin + losartan0.83 ± 0.100.75 ± 0.100.70 ± 0.090.68 ± 0.080.60 ± 0.07*
  • Data are means ± SEM. n = 5–7.

  • *Compared with basal (0 min), P < 0.01.