Age at diagnosis in all 1,384 autoimmune diabetic case subjects, irrespective of age at diagnosis, by HLA genotype (rs9271366 being too rare to analyze for age-at-diagnosis effects by age category)
| Mean age at diagnosis (years) (SD) | Genotype counts (frequency) by age-group | P | Pcat | ||||
|---|---|---|---|---|---|---|---|
| 0–21 years | 22–31 years | 32–43 years | ≥44 years | ||||
| rs660895 (DR4) | |||||||
| A/A (X/X) | 35.8 (16.4) | 97 (0.30) | 104 (0.33) | 130 (0.41) | 133 (0.44) | 4.67 × 10−6 | 2.58 × 10−4 |
| G/A (4/X) | 32.3 (15.5) | 172 (0.53) | 174 (0.54) | 146 (0.46) | 146 (0.48) | ||
| G/G (4/4) | 30.0 (14.7) | 54 (0.17) | 42 (0.13) | 41 (0.13) | 27 (0.09) | ||
| rs2187668 (DR3) | |||||||
| G/G (X/X) | 34.0 (16.3) | 187 (0.56) | 176 (0.55) | 177 (0.56) | 187 (0.61) | 0.067 | 0.51 |
| G/A (3/X) | 31.9 (15.3) | 128 (0.38) | 126 (0.39) | 118 (0.37) | 104 (0.34) | ||
| A/A (3/3) | 32.9 (13.0) | 18 (0.05) | 20 (0.06) | 21 (0.07) | 17 (0.06) | ||
| rs9271366 (DR15) | |||||||
| A/A (X/X) | 33.1 (15.9) | 320 (0.98) | 307 (0.96) | 298 (0.95) | 297 (0.96) | 0.13 | NA |
| A/G (15/X) | 36.7 (11.1) | 4 (0.01) | 12 (0.04) | 15 (0.05) | 13 (0.04) | ||
| G/G (15/15) | 37.3 (18.2) | 1 (0.00) | 0 (0.00) | 1 (0.00) | 1 (0.00) | ||
| 3/3 | 33.3 (12.9) | 16 (0.05) | 20 (0.06) | 21 (0.07) | 17 (0.06) | 1.78 × 10−7 | 0.0029 |
| 3/4 | 30.4 (14.4) | 72 (0.23) | 73 (0.23) | 57 (0.18) | 50 (0.17) | ||
| 4/4 | 30.0 (14.3) | 54 (0.17) | 41 (0.13) | 40 (0.13) | 27 (0.09) | ||
| 3/X | 33.9 (16.3) | 51 (0.16) | 49 (0.16) | 59 (0.19) | 50 (0.17) | ||
| 4/X | 33.4 (16.1) | 98 (0.31) | 99 (0.31) | 85 (0.28) | 92 (0.31) | ||
| X/X | 39.2 (17.3) | 26 (0.08) | 33 (0.10) | 47 (0.15) | 60 (0.20) | ||
NA, not analyzed. P, the P value for interaction of age at diagnosis as a continuous trait with genotype. Pcat, P value for interaction of genotype with the four age-groups corresponding to the quartiles of the age-at-diagnosis distribution.