TABLE 4

Association of HLA class II with IA-2A in 904 autoimmune diabetic case subjects, using rs660895 and rs2187668 to model HLA-DR4 and -DR3, respectively

N (frequency)OR [95% CI]P
IA-2A positiveIA-2A negative
rs660895
 G (DR4)*390 (0.42)291 (0.33)1.62 [1.31–2.00]5.45 × 10−6
rs2187668
 A (DR3)186 (0.20)260 (0.29)0.56 [0.44–0.70]3.22 × 10−7
 DR4382 (0.42)286 (0.33)1.34 [1.06–1.70]
 DR3184 (0.20)255 (0.30)0.64 [0.49–0.82]1.43 × 10−7
 4/473 (0.16)42 (0.10)1.90 [1.09–3.29]
 3/481 (0.18)96 (0.22)0.84 [0.52–1.36]
 3/321 (0.05)34 (0.08)0.54 [0.28–1.06]
 4/X155 (0.34)106 (0.25)1.59 [1.02–2.50]
 3/X61 (0.14)91 (0.21)0.68 [0.41–1.12]
 X/X61 (0.14)62 (0.14)1.00 (ref.)
  • Both DR3 and DR4 were required to model the association with IA-2A. The DR3/4/X genotype coding did not improve on the allele-specific model (P = 0.66).

  • *Uses all samples genotyped at rs660895.

  • †Uses all samples genotyped at rs2187668.

  • ‡Uses samples genotyped at both rs660895 and rs2187668. N, number of chromosomes or genotypes.