TABLE 1

Treg depletion aggravates insulin resistance

Minutes
0153045607590
Control0/84/83/82/81/81/81/8
Treg depleted2/88/86/85/86/8*7/8*7/8*
  • Db/db mice were uninephrectomized at the age of 6 weeks and followed for 56 days. One group received an anti-CD25 antibody intraperitoneally starting the day of and 4 weeks after uninephrectomy (n = 8). Control animals received an isotype control antibody (n = 8). Insulin-sensitivity testing was performed on day 56. The number of mice with blood glucose levels >600 mg/dL at the indicated time points are shown. Pooled data of two independent experiments are shown.

  • *P < 0.05 as evaluated by Fisher exact test.