Table 1

Top 30 genes upregulated in replicating β-cells, sorted from lowest FDR (Benjamini-Hochberg)

Gene symbolGene descriptionlog2(FC)FDR
Top2aTopoisomerase (DNA) II α7.43.254E-137
Cdk1Cyclin-dependent kinase 17.45.773E-135
HmmrHyaluronan-mediated motility receptor (RHAMM)7.31.779E-125
PbkPDZ-binding kinase6.93.012E-125
CenpfCentromere protein F7.01.478E-123
Iqgap3IQ motif containing GTPase-activating protein 38.31.26E-122
Nusap1Nucleolar and spindle–associated protein 17.22.723E-122
Arhgef39ρ Guanine nucleotide exchange factor (GEF) 398.21.213E-120
Cdca3Cell division cycle–associated 36.84.879E-118
Cdca8Cell division cycle–associated 87.04.879E-118
Neil3Nei-like 3 (Escherichia coli)7.66.64E-118
Cdc20Cell division cycle 206.94.026E-117
AurkbAurora kinase B7.71.448E-116
Plk1Polo-like kinase 17.71.447E-115
Tpx2TPX2, microtubule-associated protein homolog (Xenopus laevis)6.75.782E-115
TroapTrophinin-associated protein8.02.113E-114
Fam64aFamily with sequence similarity 64, member A7.38.469E-114
Ckap2lCytoskeleton-associated protein 2–like6.71.681E-113
CenpaCentromere protein A6.62.528E-113
CenpeCentromere protein E6.95.374E-113
Birc5Baculoviral IAP repeat-containing 56.72.244E-112
Ccnb2Cyclin B26.59.707E-112
Ska1Spindle and kinetochore–associated complex subunit 18.29.707E-112
Ccna2Cyclin A26.51.469E-111
Mxd3Max dimerization protein 37.22.387E-111
Casc5Cancer susceptibility candidate 57.55.009E-108
AspmAbnormal spindle–like, microcephaly associated (Drosophila)6.78.609E-106
Ankle1Ankyrin repeat and LEM domain–containing 17.59.805E-106
Kif23Kinesin family member 236.89.805E-106
Shcbp1Shc SH2-domain–binding protein 16.98.241E-104
  • DESeq was used to normalize the counts and compute log twofold change [log2(FC)] and FDR.