Table 3

Genes involved in secretion, encoding for insulin granule proteins, and regulating GSIS and repressed in replicating β-cells

Secretion genesInsulin granule genesGenes regulating GSIS
Genelog2(FC)FDRGenelog2(FC)FDRGenelog2(FC)FDR
Sec23b−0.737.80E-03Rab3a−0.831.38E-02Slc2a2−1.381.25E-08
Uso1−1.191.4E-06Ctsd−0.614.15E-02G6pc2−1.837.85E-15
Trappc4−0.673.01E-02Cpn1−1.269.54E-03Idh1−1.921.50E-13
Scamp1−1.101.78E-05Ctsl−1.651.24E-11Slc25a1−0.692.10E-02
Osbpl5−1.051.40E-03Scg5−1.068.27E-03Glud1−0.862.11E-03
Syn2−0.901.65E-03Hspa5−0.613.05E-02Ucn3−0.672.23E-02
Rab3a−0.831.38E-02Tcn2−1.242.71E-06
Mcfd2−0.949.96E-03Pcsk2−0.729.36E-03
Tpd52−0.701.34E-02Sytl4−0.765.06E-03
Rab3d−0.937.59E-03Pdia3−0.661.86E-02
Sytl4−0.765.06E-03Clu−0.741.16E-02
Arfgap3−0.748.03E-03Cpe−0.821.99E-03
Stx4a−0.693.40E-02Aldoa−2.831.46E-31
Stxbp3a−1.105.88E-05
Blzf1−1.016.95F-04
Srp54c−0.942.62E-03
Sec23a−0.941.62E-03
Sar1b−0.832.66E-03
Snap23−1.123.80E-05
Copb2−0.952.40E-04
Scg5−1.068.27E-03
Unc13b−0.643.77E-02
Scfd1−1.091.65E-05
Sar1a−0.774.18E-03
Gars−0.613.21E-02
Rab1−0.652.34E-02
Cog1−0.633.09E-02
Rab27a−0.962.08E-04
Myo6−0.594.56E-02
  • FDR (Benjamini-Hochberg) and log twofold change [log2(FC)] as calculated by DESeq after count normalization.