Table 6

Association of rs7533564 with skin biopsy AGEs

Skin AGEUnivariableMultivariable*
NMean (SD)β (SE)Pβ (SE)P
Pepsin soluble collagen (%)*1701.78 (0.47)−0.243 (0.169)0.150−0.157 (0.152)0.303
Acid soluble collagen (%)*170−0.72 (0.51)−0.020 (0.185)0.913−0.013 (0.181)0.942
Fluorescence (AU)*1705.21 (0.26)0.148 (0.095)0.1240.109 (0.083)0.189
Furosine (pmol/mg collagen)*1676.60 (0.29)0.214 (0.112)0.0570.084 (0.089)0.349
Pentosidine (pmol/mg collagen)*1663.21 (0.37)0.187 (0.133)0.1600.132 (0.085)0.126
Nε-carboxymethyl-lysine (pmol/mg collagen)16913.38 (5.21)0.365 (1.892)0.8470.124 (1.757)0.944
Carboxyethyl-lysine (pmol/mg)*1694.79 (0.65)−0.106 (0.237)0.654−0.118 (0.241)0.625
Methylglyoxal hydroimidazolones (nmol/mg)*170−0.37 (0.55)0.156 (0.198)0.4320.160 (0.184)0.385
Glyoxal hydroimidazolones (pmol/mg)1697.84 (1.97)1.379 (0.707)0.0531.374 (0.694)0.049
Fructose-lysine (nmol/mg)*1701.63 (0.37)0.250 (0.133)0.0620.177 (0.118)0.135
Glucosepane (nmol/mg)*1700.90 (0.31)0.176 (0.112)0.1170.110 (0.088)0.210
Total glucose bound (fructose-lysine plus glucosepane)*1702.04 (0.30)0.226 (0.109)0.0390.154 (0.098)0.117
LW117019.36 (5.01)2.004 (1.814)0.2711.210 (1.621)0.456
  • Association of the identified SNP with skin biopsy AGEs was tested using linear regression. The results were further adjusted for age, duration of diabetes, and treatment group in the multivariable analysis. AU, arbitrary units.

  • *Natural log transformed.

  • †Square root transformed.