Table 1

T1D-GRS is discriminatory for T1D and MODY

Categories based on GRS centiles of T1D cohort (actual score value)T1D, n (%)Confirmed MODY, n (%)TotalOdds ratio for T1D (95% CI)
<5th centile (<0.234)98 (5)423 (53)5211
5–25th centile (0.234–0.262)392 (20)242 (30)6347 (5–9)
26–50th centile (0.263–0.280)492 (25)89 (11)58124 (16–36)
51–75th centile (0.281–0.299)491 (25)42 (5)53350 (29–89)
>75th centile (>0.299)490 (25)9 (1)499235 (73–755)
Total1,963 (100)805 (100)2,768
  • The groups were categorized by GRS centiles of the T1D cohort. The odds ratios are relative to <5th centile of T1D-GRS category.