Table 2

Top 30 most significantly induced genes in replicating β-cells not previously annotated as cell cycle regulated and not present in cell cycle–related gene sets

Gene nameGene descriptionlog2(FC)FDR
Sapcd2Suppressor APC domain–containing 26.88.4E-102
D17H6S56E-5DNA segment, Chr17, human D6S56E55.42.37E-91
Tcf19Transcription factor 195.26.63E-81
4930579G24RikRIKEN cDNA 4930579G245.62.97E-78
BC030867cDNA sequence BC0308677.26.79E-70
Slc9a5Solute carrier family 9 (sodium/hydrogen exchanger), member 56.31.24E-59
Mtfr2Mitochondrial fission regulator 25.91.61E-59
Sez6Seizure-related gene 66.92.4E-59
Trim59Tripartite motif–containing 594.32.11E-57
Pbx4Pre–B-cell leukemia homeobox 45.22.74E-55
Depdc1aDEP domain–containing 1a6.62.62E-54
4930427A07RikRIKEN cDNA 4930427A07 gene4.28.27E-53
Ccdc18Coiled-coil domain–containing 186.78.68E-52
Ccdc34Coiled-coil domain–containing 343.91.71E-50
Cyp39a1Cytochrome P450, family 39, subfamily a, polypeptide 14.04.44E-48
Rgs12Regulator of G-protein signaling 124.65.37E-47
Zfp367Zinc finger protein 3673.53.44E-43
4930452B06RikRIKEN cDNA 4930452B06 gene5.23.43E-42
2700094K13RikRIKEN cDNA 2700094K13 gene3.35.08E-41
Zgrf1Zinc finger, GRF-type–containing 13.91.46E-39
Katnal2Katanin p60 subunit A-like 23.92.51E-37
Serpinb8Serine (or cysteine) peptidase inhibitor, clade B, member 84.81.1E-35
Tbc1d31WD repeat domain 673.31.94E-35
BC055324cDNA sequence BC0553244.52.21E-33
Ccdc77Coiled-coil domain–containing 773.07.38E-30
Rgs3Regulator of G-protein signaling 33.23.04E-28
Heatr7b1Maestro heat-like repeat family member 2A3.58.15E-27
Dnph12'-deoxynucleoside 5′-phosphate N-hydrolase 14.23.6E-26
LrddLeucine-rich and death domain–containing3.34.54E-26
Neurl1bNeuralized homolog lb (Drosophila)5.35.67E-26
  • List of 30 genes compiled from cell cycle–GO categories, Whitfield cell cycle, and Benporath cycling genes from MSigDB. Genes associated with cancer (candidate oncogenes, tumor suppressor genes, or genes highly expressed in cancer) appear in boldface type. DESeq was used to normalize counts, compute log twofold change [log2(FC)], and calculate FDR (Benjamini-Hochberg).