Table 3

Summary of change in gene expression of PBMC with tRES-HESP coformulation in the HATFF study

Study groupnGenes
IncreasedDecreased
All29GLO1 (6%)HIF1A (−6%), IL8 (−39%), and PTGS2 (−30%)
Highly overweight/obese20FTH1 (−19%), HIF1A (−8%), IL8 (−49%), PTGS2 (−31%), RAGE (−37%), and CCL2 (−49%)
Obese11CCL2 (−22%), HIF1A (−7%), IL8 (−62%), KEAP1 (−18%), PTGS2 (−37%), and TNFA (−12%)