Table 2

Metabolites that significantly differ in incident T2D in the training set (n = 80 pairs)

No.MetabolitesNon-T2DIncident T2DUncorrected P valueCorrected P value*
12-AAA1.06 ± 0.441.27 ± 0.548.02E-031.01E-01
2Gly311.1 ± 112.63279.14 ± 71.73.38E-022.31E-01
3Ile46.94 ± 9.0951.39 ± 11.88.30E-031.01E-01
4Leu115.05 ± 21.79126.34 ± 29.016.05E-039.50E-02
5Thr141.13 ± 27.78154.77 ± 43.811.99E-021.83E-01
6Trp66.76 ± 8.3170.52 ± 10.991.57E-021.57E-01
7Tyr94.82 ± 17.48106.33 ± 24.517.95E-042.23E-02
8Val230.79 ± 35.52252.44 ± 45.631.01E-032.23E-02
9xLeu+200.69 ± 29.18220.64 ± 43.678.63E-042.23E-02
10Hexoses4.7 ± 0.515.16 ± 0.631.13E-061.24E-04
11SM (OH) C16:12.87 ± 0.692.62 ± 0.83.87E-022.31E-01
12SM (OH) C22:27.13 ± 1.456.59 ± 1.833.90E-022.31E-01
13SM C18:017.21 ± 3.8315.82 ± 4.192.98E-022.31E-01
14SM C18:18.91 ± 2.017.94 ± 2.214.11E-037.54E-02
15SM C20:20.42 ± 0.120.34 ± 0.121.33E-047.33E-03
16SM C24:126.86 ± 5.5224.52 ± 6.441.47E-021.57E-01
17PC ae C40:54.81 ± 1.214.36 ± 1.594.32E-022.31E-01
18PC ae C42:52.27 ± 0.462.08 ± 0.592.42E-022.05E-01
19PC ae C44:51.18 ± 0.251.09 ± 0.324.47E-022.31E-01
20AC100.25 ± 0.080.22 ± 0.064.63E-022.31E-01
21AC30.28 ± 0.080.31 ± 0.14.55E-022.31E-01
22Palmitoleic acid (C16:1 n9)2.76 ± 0.962.45 ± 0.863.86E-022.31E-01
  • Data are presented as the mean ± SD, unless otherwise noted. Concentrations of metabolites are in μmol/L except for hexoses (mmol/L).

  • *P values are corrected for multiple comparisons with the Benjamini-Hochberg method and significant metabolites are shown in boldface type.

  • +Metabolites assayed using both Biocrates plate technology and in-house method, but xLeu was excluded for prediction analysis. Significant differences after Benjamini-Hochberg correction for multiple comparisons are shown in boldface type.