Table 1

Anthropometric measures and clinical biochemistry at start of clamp, presurgery and postsurgery

PresurgeryPostsurgery
Age (years)43.1 (10.8)
Height (m)1.69 (0.09)
Weight (kg)A116.5 (15.7)86.4 (16.2)***
BMI (kg/m2)40.6 (3.1)30.1 (4.3)***
Body fat (%)B43.3 (7.4)36.0 (7.4)***
Body surface (m2)2.25 (0.2)1.96 (0.2)***
Systolic BP initial (mmHg)126 (12)121 (12)*
Diastolic BP initial (mmHg)81 (9)75 (5)
Heart rate (bpm)65 (8)56 (10)***
Hemoglobin (g/L)140.5 (10.7)133.6 (10.1)*
Plasma creatinine (μmol/L)75.8 (12.7)66.7 (9.8)***
eGFR (mL/min/1.73 m2)82.2 (5.3)88.1 (3.2)**
Plasma albumin (g/L)35.2 (2.7)34.7 (3.2)
HOMA-IR6.32 (2.2)1.96 (1.0)***
Fasting plasma glucose (mmol/L)5.9 (0.5)5.4 (0.4)***
HbA1c [% (mmol/mol)]5.5 (1.5) (37.4 [4.6])5.2 (1.3) (32.8 [3.1])***
Serum insulin (mU/L)22.3 (10.1)8.1 (4.1)***
Serum C-peptide (nmol/L)1.4 (0.3)0.9 (0.2)***
Plasma cholesterol (mmol/L)4.7 (1.0)*3.8 (0.8)***
Plasma HDL cholesterol (mmol/L)1.0 (0.3)1.0 (0.3)
Plasma LDL cholesterol (mmol/L)3.1 (0.8)*2.3 (0.7)***
Plasma triglycerides (mmol/L)1.7 (0.7)*1.1 (0.3)**
Glucagon (pmol/L)13.4 (6.9)8.6 (5.4)**
Cortisol (nmol/L)233 (99.8)199 (49.0)
GH (μg/L)0.18 (0.3)1.3 (3.1)
Epinephrine (nmol/L)0.3 (0.001)0.3 (0.06)
Norepinephrine (nmol/L)1.4 (0.7)1.1 (0.3)
GLP-1 (pmol/L)33.5 (36.5)18.7 (13.4)
GIP (pg/mL)55.9 (27.4)40.0 (12.0)*
FFAs (μmol/L)203 (55.8)219 (64.8)
Glycerol (μmol/L)60.0 (17.1)61.6 (27.1)
  • Values are reported as the mean (SD). BP, blood pressure; eGFR, estimated glomerular filtration rate; IR, insulin resistance.

  • AWeight on the day of surgery (112 kg) was not significantly changed compared with presurgery weight at clamp investigation.

  • BMeasured with bioimpedance.

  • *P < 0.05; **P < 0.01; ***P < 0.001.