Table 4

Pearson correlation coefficients (r) between 22 metabolites that significantly differ in incident T2D compared with non-T2D, as well as metabolite selected by machine learning (SM (OH) C14:1), in the training set (80 pairs) at baseline and clinical parameters BMI, FPG, 2hPG, fasting insulin, and HOMA-IR at baseline

Parameter and metaboliteBMI (kg/m2)Fasting glucose (mg/dL)2hPG (glucose mg/dL)Fasting insulin (μU/mL)HOMA-IR
2-AAA0.210**0.283***0.1150.335***0.353***
Gly−0.151+−0.192*−0.173*−0.279***−0.281***
Ile0.230**0.278***0.1440.415***0.437***
Leu0.0550.242**0.15*0.343***0.367***
Thr0.218**0.156*0.0250.150+0.153+
Trp−0.161*0.22**0.0610.171*0.187*
Tyr0.205**0.252**0.0280.335***0.353***
Val0.0730.235**0.161*0.409***0.418***
AC10−0.022−0.165*0.139−0.201*−0.202*
AC30.1040.306***0.184*0.362***0.387***
xLeu+0.1180.311***0.197*0.481***0.508***
Hexoses0.16*0.826***0.211**0.311***0.429***
Palmitoleic acid (C16:1n9)0.246**−0.1−0.0090.0980.068
PC ae C40:5−0.252**−0.0540.081−0.329***−0.311***
PC ae C42:5−0.115−0.0330.018−0.266***−0.252**
PC ae C44:5−0.006−0.177*−0.182*−0.204**−0.217**
SM C18:0−0.181*−0.150*0.028−0.266***−0.272***
SM C18:1−0.049−0.157*−0.039−0.254**−0.263***
SM C20:2−0.092−0.284***−0.122−0.358***−0.376***
SM C24:1−0.277***−0.246**−0.025−0.475***−0.475***
SM (OH) C14:1−0.136−0.207*−0.175*−0.257**−0.279***
SM (OH) C16:1−0.161*−0.199*−0.087−0.315***−0.329***
SM (OH) C22:2−0.201*−0.226**−0.034−0.378***−0.385***
  • +P = 0.05.

  • *P < 0.05.

  • **P < 0.005.

  • ***P < 0.0005.