Table 1

Estimates from the application of IVW, MR-Egger, and weighted median MR methodologies

MethodEstimate95% CIP value
Complete variant set (n = 96 SNPs)
 IVW1.201.09, 1.308.00 × 10−05
 MR-Egger1.391.14, 1.681.53 × 10−03
 MR-Egger*−0.019−0.041, 0.0040.10
 Weighted median1.261.17, 1.345.26 × 10−9
TCF7L2(rs7903146) removed from the variant set (n = 95 SNPs)
 IVW1.221.16, 1.281.49 × 10−11
 MR-Egger1.341.17, 1.519.71 × 10−06
 MR-Egger*−0.011−0.024, −0.0240.13
 Weighted median1.261.19, 1.323.29 × 10−10
FTO(rs1558902) removed from the variant set (n = 95 SNPs)
 IVW1.161.06, 1.271.31 × 10−03
 MR-Egger1.301.01, 1.650.04
 MR-Egger*−0.012−0.038, 0.0140.34
 Weighted median1.211.13, 1.286.81 × 10−08
  • Estimates represent the estimated causal effect of BMI on type 2 diabetes.

  • *The average pleiotropic effect of a genetic variant on type 2 diabetes risk.