Table 1

Cohort and participant demographics

CohortParticipants (n)Female (%)Age (years)BMI (kg/m2)Fasting glucose (mmol/L)Fasting insulin (pmol/L)Stumvoll ISI ([μmol * pmol]/[kg * min * L])
Discovery
 FHS2,6025454.0 ± 9.926.8 ± 4.55.2 ± 0.528.6 ± 9.90.111 ± 0.012
 Sorbs8026046.3 ± 15.926.5 ± 6.45.5 ± 1.240.7 ± 26.50.105 ± 0.023
 FUSION4626366.5 ± 6.727.6 ± 4.25.1 ± 0.568.5 ± 36.00.087 ± 0.023
 CHS2,7616272.3 ± 5.326.0 ± 4.35.5 ± 0.593.3 ± 47.80.059 ± 0.038
 LURIC9622461.9 ± 27.127.1 ± 3.85.5 ± 0.661.6 ± 49.90.065 ± 0.038
 ULSAM962071.0 ± 0.626.0 ± 3.25.4 ± 0.673.0 ± 40.10.074 ± 0.031
 METSIM7,388057.0 ± 6.9626.8 ± 3.85.7 ± 0.549.8 ± 35.30.093 ± 0.030
Replication
 EUGENE28855639.4 ± 9.226.5 ± 4.85.1 ± 0.549.0 ± 34.90.091 ± 0.028
 Amish Studies3346145 ± 12.727.4 ± 4.74.9 ± 0.563.4 ± 26.00.09 ± 0.02
 RISC9215644 ± 8.3725.5 ± 4.05.1 ± 0.634.4 ± 18.70.106 ± 0.018
 Tübingen2,4706540.2 ± 13.230.9 ± 9.65.2 ± 0.683.4 ± 72.20.070 ± 0.049
 Inter995,3185145.9 ± 7.926.1 ± 4.45.5 ± 0.541.1 ± 26.30.101 ± 0.021
 Segovia4205352.1 ± 11.426.7 ± 3.84.5 ± 0.671.2 ± 39.70.087 ± 0.025
 Pizarra6406643.6 ± 13.027.8 ± 4.95.4 ± 0.746.6 ± 34.20.101 ± 0.023
 Botnia Study1,2355258.3 ± 10.227.1 ± 3.95.4 ± 0.544.7 ± 28.70.099 ± 0.020
 1936 Birth Cohort5765460.5 ± 0.526.5 ± 4.05.2 ± 0.542.5 ± 23.70.098 ± 0.022
 Ely Study1,4425461.1 ± 9.227.3 ± 4.85.0 ± 0.657.1 ± 35.70.088 ± 0.031
  • Continuous results are shown as mean ± SD. Additional information for each cohort can be found in Supplementary Table 1.