Table 3

Partial Spearman correlation coefficients of IGF-I, IGFBP-2, and IGFBP-3 concentrations and molar ratio of IGF-I to IGFBP-3 at gestational weeks 10–14 with subsequent fasting plasma biomarkers at gestational weeks 15–26 among case subjects with GDM and control subjects without GDM^*

	HOMA-IR	Glucose	Insulin	CRP
Case subjects
IGF-I	0.24^†	0.12	0.25^†	−0.22^†
IGFBP-2	−0.34^‡	−0.25^†	−0.33^§	−0.05
IGFBP-3	−0.12	−0.02	−0.13	−0.14
Molar ratio of IGF-I to IGFBP-3	0.36^‡	0.13	0.37^‡	−0.21^†
Control subjects
IGF-I	0.17^†	0.002	0.18^†	−0.07
IGFBP-2	−0.27^‡	−0.02	−0.28^‡	−0.11
IGFBP-3	0.04	0.04	0.04	0.04
Molar ratio of IGF-I to IGFBP-3	0.15^†	−0.05	0.17^†	−0.13

*P values were adjusted for age, gestational age at blood collection, family history of diabetes, and prepregnancy BMI.
†P < 0.05.
‡P < 0.001.
§P < 0.01.