Table 4

Estimated change in percentage (95% CI) in early and late glucagon suppression by a doubling in insulin sensitivity

Early glucagon suppressionLate glucagon suppression
EstimateP valueEstimateP value
Model 128.0 (21.0; 35.0)<0.001−12.4 (−16.4; −8.4)<0.001
Model 220.5 (6.3; 34.7)0.005−8.9 (−16.8; −1.0)0.027
Model 311.5 (−0.9; 23.8)0.069−10.6 (−18.3; −2.9)0.007
  • Model 1, adjustment for age, sex, and fasting glucagon (early suppression as outcome) or 30-min glucagon level (late suppression as outcome); model 2, further adjustment for fasting and 2-h plasma glucose level; and model 3, further adjustment for relative change in GIP and GLP-1 (from 0 to 30 min for early suppression as outcome and from 30 to 120 min for early suppression as outcome).