Table 1

Pancreas donor qualifications

RequirementYesNoNA
A qualified donor must have yes responses to all the inclusion criteria (A), and no responses to all the exclusion criteria (B and C).
Container label must specify human pancreas, and an UNOS or a DDD number must be present.
The organ procurement organization must be identified.
A. Inclusion criteria (The donor or pancreas must meet these criteria.)
 1. Pancreas preservation in (i) UW, (ii) PFC/UW, (iii) HTK, or (iv) PFC/HTK solutions
 2. Maximum 12-h cold ischemia time
 3. Donor age 15–65 years
 4. Cause and circumstances of death acceptable to the transplant team
B. Exclusion criteria (Is there evidence of the following conditions?)
 1. History or biochemical evidence of type 1 or 2 diabetes (Transplant teams may consider donor HbA1c >6.1% in the absence of transfusions in the week before death as an indication for exclusion, with discretion for donors who have received transfusions.)
 2. Pancreas from non—heart-beating cardiac death donors
 3. Malignancies, other than resected basal squamous cell carcinoma or intracranial tumor as the cause of death
 4. Suspected or confirmed sepsis
 5. Evidence of clinical or active viral hepatitis (A, B [HBcAg], C). HBsAb positive is acceptable if there is a history of vaccination.
 6. AIDS
 7. HIV seropositivity (HIV-I or HIV-II) or HIV status unknown
 8. HTLV-I or HTLV-II (optional)
 9. Syphilis (RPR or VDRL positive)
 10. Active viral encephalitis or encephalitis of unknown origin
 11. TSE or Creutzfeldt-Jakob disease
 12. Suspected rabies diagnosis
 13. Treated or active tuberculosis
 14. Individuals who have received pituitary human growth hormone
 15. Any medical condition that, in the opinion of the transplant team, precludes a reasonable possibility of a favorable outcome of the islet transplant procedure
 16. Clinical history and/or laboratory testing suggestive of West Nile virus, vaccinia, or SARS
C. Exclusion criteria—behavioral profiles (Is there evidence of the following conditions?)
 17. High-risk sexual behavior within 5 years before time of death: men who have had sex with men, individuals who have engaged in prostitution, and individuals whose sexual partners have engaged in high-risk sexual behavior
 18. Nonmedical intravenous, intramuscular, or subcutaneous drug use within the past 5 years
 19. Persons with hemophilia or related clotting disorders who have received human-derived clotting factor concentrates
 20. Findings on history or physical examination consistent with an increased risk of HIV exposure
 21. Current inmates of correctional systems and individuals who have been incarcerated for >72 consecutive hours during the previous 12 months
  • DDD, donor-derived disease; HBcAg, hepatitis B core antigen; HBsAb, hepatitis B surface antibody; HTK, histidine-tryptophan-ketoglutarate; HTLV, human T-cell lymphoma; NA, not applicable; PFC, perfluorocarbon; RPR, rapid plasma reagin; SARS, severe acute respiratory syndrome; TSE, transmissible spongiform encephalopathy; UNOS, United Network for Organ Sharing; UW, University of Wisconsin; VDRL, venereal disease research laboratory.