Table 3

Glucagon characteristics in individuals with different subtypes of screen-detected diabetes

F-D(N = 80)2h-D(N = 42)F-2h-D(N = 37)P value
Fasting glucagon (pmol/L)8.8 (7.3; 10.6)14.3 (11.8; 17.3)a14.8 (12.9; 17)a<0.001
30-min glucagon (pmol/L)9.3 (8.0; 10.8)13.9 (12.1; 16.1)a15.9 (13.8; 18.3)a<0.001
120-min glucagon (pmol/L)5.6 (4.8; 6.5)6.5 (5.4; 8.0)6.9 (5.7; 8.3)0.355
Glucagon suppression, 30 min (%)*−6.2 (−21.6; 7.3)2.3 (−10.7; 13.8)−7.4 (−17.7; 2.1)0.613
Glucagon suppression, 30–120 min (%)ǂ41.0 (33.4; 47.7)53.1 (47.1; 58.3)a56.6 (51.5; 61.2)a0.001
Glucagon suppression, 120 min (%)§37.1 (28.7; 44.4)54.2 (46.3; 60.8)a53.4 (47.7; 58.5)a<0.001
  • Data are geometric mean (95% CI), unless otherwise indicated. F-D, diabetes diagnosed by fasting glucose only; 2h-D, diabetes diagnosed by 2-h glucose only; F-2h-D, diabetes diagnosed by both fasting and 2-h glucose levels.

  • aP < 0.05 vs. NGT.

  • *Calculated as: (1 − [glucagon30 min/glucagon0 min]) × 100.

  • ǂCalculated as: (1 − [glucagon120 min/glucagon30 min]) × 100.

  • §Calculated as: (1 − [glucagon120 min/glucagon0 min]) × 100.