Table 2

Glucagon characteristics in individuals with different subtypes of prediabetes

i-IFG(N = 281)i-IGT(N = 110)IFG+IGT(N = 123)P value
Fasting glucagon (pmol/L)9.7 (9; 10.5)9.8 (8.6; 11.1)10.6 (9.3; 11.9)0.190
30-min glucagon (pmol/L)8.7 (8.1; 9.3)8.9 (8.2; 9.8)9.7 (8.8; 10.7)0.144
120-min glucagon (pmol/L)5.8 (5.4; 6.3)4.9 (4.4; 5.4)a5.1 (4.5; 5.6)a0.002
Glucagon suppression, 0–30 min (%)*10.4 (5.2; 15.4)8.5 (−0.1; 16.3)8.2 (0.1; 15.7)0.864
Glucagon suppression, 30–120 min (%)ǂ33.1 (29.6; 36.5)45.2 (40.8; 49.3)a47.8 (43.0; 52.3)a<0.001
Glucagon suppression, 0–120 min (%)§39.8 (35.8; 43.6)49.7 (45.2; 53.9)a52.1 (47.5; 56.3)a<0.001
  • Data are geometric mean (95% CI), unless otherwise indicated. i-IFG, isolated IFG; i-IGT, isolated IGT; IFG+IGT, combined IFG and IGT.

  • aP < 0.05 vs. NGT.

  • *Calculated as: (1 − [glucagon30 min/glucagon0 min]) × 100.

  • ǂCalculated as: (1 − [glucagon120 min/glucagon30 min]) × 100.

  • §Calculated as: (1 − [glucagon120 min/glucagon0 min]) × 100.