Metabolites significantly associated with metformin treatment in mouse models
| Metabolite | In plasma | In liver | In skeletal muscle | In adipose tissue | ||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) per SD | P value | β (95% CI) per SD | P value | β (95% CI) per SD | P value | β (95% CI) per SD | P value | |
| Citrulline | −0.39 (−0.49, −0.28) | 2.56E-07 | −0.02 (−0.06, 0.02) | 0.258 | −0.35 (−0.41, −0.28) | 1.79E-09 | −0.26 (−0.33, −0.19) | 4.52E-07 |
| X-21365 | −0.08 (−0.24, 0.08) | 0.311 | −0.12 (−0.34, 0.11) | 0.295 | −0.12 (−0.27, 0.04) | 0.126 | −0.23 (−0.46, 0.01) | 0.063 |
Estimates (β) and P values for the comparison between metformin-treated (n = 10, in skeletal muscle [n = 9]) and nontreated mice (n = 10) sacrificed at 4 h after the last treatment. Significant metabolites are highlighted in boldface type (P < 0.05).