Table 5

Metabolites significantly associated with metformin treatment in mouse models

MetaboliteIn plasmaIn liverIn skeletal muscleIn adipose tissue
β (95% CI) per SDP valueβ (95% CI) per SDP valueβ (95% CI) per SDP valueβ (95% CI) per SDP value
Citrulline−0.39 (−0.49, −0.28)2.56E-07−0.02 (−0.06, 0.02)0.258−0.35 (−0.41, −0.28)1.79E-09−0.26 (−0.33, −0.19)4.52E-07
X-21365−0.08 (−0.24, 0.08)0.311−0.12 (−0.34, 0.11)0.295−0.12 (−0.27, 0.04)0.126−0.23 (−0.46, 0.01)0.063
  • Estimates (β) and P values for the comparison between metformin-treated (n = 10, in skeletal muscle [n = 9]) and nontreated mice (n = 10) sacrificed at 4 h after the last treatment. Significant metabolites are highlighted in boldface type (P < 0.05).