Table 1

Effects of significant hits identified in a primary screen for β-cell dysfunction

GeneLocusLow glucoseHigh glucoseIBMXTolbutamideCell count
ABCC8KCNJ1148.2*24.026.7*1.8−1.4
ADAMTS9ADAMTS96.3−4.82.8−8.012.2*
ADIPOQST64GAL187.0*23.223.18.8−7.3
ARL15ARL15−5.5−25.9*−2.1−15.5−1.5
BCAR1BCAR15.925.228.5*9.5−7.0
BCL6LPP−20.7*−8.9−1.0−12.05.6
BMP8BMACF17.816.59.526.9*−1.0
CCNT2TMEM163−32.6*1.84.75.0−2.8
CDKAL1CDKAL12.41.7−10.6−23.5*7.5
DGKQMAEA3.317.520.433.6*−9.8
DMRTA2FAF132.3*24.513.122.7−0.3
ELAVL4FAF1−3.69.121.222.8−11.4*
ETV5IGF2BP2−12.4−25.6*−10.9−12.6−2.5
FAHZFAND6−23.1*−20.6*−16.9−27.2−2.3
FBXW7TMEM15445.2*9.68.711.79.9*
GINS4ANK1−16.1−14.2−9.5−17.08.7*
GLIS3GLIS3−13.0−10.66.4−9.3−10.3*
HEYLMACF129.229.2*0.420.0−7.2
HMGA2HMGA216.54.114.224.1*−1.2
HNF1AHNF1A21.738.3*23.125.5*5.2
HNF4AHNF4A36.7*66.9*74.992.9*−8.8
IGF2DUSP8−26.3*−10.41.20.1−1.3
INSDUSP8−53.5*−44.8*−48.7−38.7*0.9
KCNK17KCNK16−9.4−17.3−2.5−1.29.8*
KCTD15PEPD21.79.412.50.8−10.9*
KIF11HHEX/IDE45.4*35.0*26.955.4*−40.1*
LINGO1HMG20A019.1−12.4−14.97.9*
MFGE8AP3S230.0*3.42.8−1.7−5.7
MIER3ANKRD555.936.5*5.818.21.9
NDUFS4ARL151.6−4.93.9−1.710.8*
PABPC1LHNF4A−9.7−12.3−10.4−28.8*−1.2
PHF23SLC16A11−25.6*−1.7−5.93.5−0.9
PLA2R1RBMS18.61.610.81.69.1*
PRDX3GRK524.031.7*23.49.616.6*
PTHLHKLHDC5−2.8−6.5−0.5−25.0*−5.9
RND3RND3−8.7−6.10−3.0−14.9*
SLC2A4SLC16A1114.5027.2*18.2−1.6
SOCS7HNF1B3.9−18.5*11.2−14.7−1.6
SPPL3HNF1A−11.9−21.9*−6.1−10.0−10.8*
STK38LKLHDC515.240.9*4.725.2*−3.0
THADATHADA−1.96.527.524.8*−10.3
TLE1TLE14.3−5.0−23.0*16.24.6
TM6SF2CILP2−22.6*−8.3−0.8−12.0−8.7
UPF2CDC1237.5−12.54.7−24.9*−3.2
ZMIZ1ZMIZ1−29.5*−21.4*−19.8−16.8−15.2*
  • The table lists effect sizes (% deviation from NT control) for each gene with a least one significant effect across the five phenotypes measured. All insulin secretion measurements were normalized on a per-well basis to cell counts, and the mean percentage deviations from NT control were then calculated for each condition. For cell counts, values were median-normalized for interplate differences, and the mean percentage deviations from NT control were calculated across conditions.

  • *q < 0.05 by Student t test (FDR-adjusted).