Table 4

Ox-LDL–mediated fraction of the effect of waist circumference on metabolic syndrome–related parameters

Outcome (per cm of waist)TotalDirectMediatedMediated %
BMI, kg/m20.31630.3172−0.0009
(0.3094, 0.3234)(0.3104, 0.3243)(−0.0017, −0.0001)
P < 0.001P < 0.001P = 0.02
Triglycerides, mg/dL1.35571.16710.188613.9
(1.1851, 1.5279)(0.9944, 1.3415)(0.1358, 0.2497)(10.1, 18.5)
P < 0.001P < 0.001P < 0.001P < 0.001
HDL-cholesterol, mg/dL−0.3364−0.3276−0.00882.6
(−0.3714, –0.3023)(−0.3623, –0.2921)(−0.0139, −0.0042)(1.2, 4.2)
P < 0.001P < 0.001P < 0.001P < 0.001
Total cholesterol, mg/dL−0.0648−0.09380.0290
(−0.1042, –0.0210)(−0.1334,–0.0480)(0.0193, 0.0394)
P = 0.006P < 0.001P < 0.001
Systolic blood pressure, mmHg0.32330.31430.00912.8
(0.2876, 0.3595)(0.2771, 0.3515)(0.0041, 0.0147)(1.3,4.6)
P < 0.001P < 0.001P < 0.001P < 0.001
Diastolic blood pressure, mmHg0.34100.33520.00581.7
(0.3122, 0.3702)(0.3058, 0.3657)(0.0020, 0.0095)(0.6, 2.8)
P < 0.001P < 0.001P < 0.001P < 0.001
Fasting glucose, mg/dL0.25400.2551−0.0011
(0.2281, 0.2788)(0.2286, 0.2798)(−0.0047, 0.0025)
P < 0.001P < 0.001P = 0.52
Insulin, pmol/L0.19460.19230.00231.2
(0.1834, 0.2075)(0.1808, 0.2051)(0.0007, 0.0040)(0.4, 2.1)
P < 0.001P < 0.001P = 0.008P = 0.008
HOMA-IR, log0.03290.03280.00010.3
(0.0312, 0.0346)(0.0311, 0.0344)(−0.0001, 0.0003)(−0.3, 1.0)
P < 0.001P < 0.001P = 0.29P = 0.29
HbA1c, %0.00310.00290.00025.3
(0.0018, 0.0042)(0.0016, 0.0041)(0.0000, 0.0003)(−0.1, 13.7)
P < 0.001P < 0.001P = 0.05P = 0.05
  • The columns show the total effect, direct effect, and ox-LDL–mediated effect of waist circumference on each MS-related parameter and the proportion of the total effect of waist circumference that is mediated by ox-LDL. Data in parentheses show the 95% CI calculated by nonparametric bootstrapping. The basic adjustment model was used (age, sex, smoking status, and LDL-cholesterol).