Expanded set (n = 28) | Conservative set (n = 13) | |||||
---|---|---|---|---|---|---|

OR^{*} | 95% CI | P | OR^{*} | 95% CI | P | |

Cumulative GRS^{†}^{‡} | 1.018 | 1.009–1.028 | 9.1 × 10^{−5} | 1.021 | 1.008–1.033 | 1.5 × 10^{−3} |

Unweighted GRS^{†}^{‡} | 1.008 | 1.003–1.013 | 2.0 × 10^{−3} | 1.008 | 1.001–1.015 | 0.018 |

Weighted-median GRS^{§} | 1.018 | 1.006–1.033 | < 0.05 | 1.020 | 1.003–1.039 | < 0.05 |

Egger regression (causal estimate)^{§}|| | 1.043 | 1.006–1.064 | 5.5 × 10^{−3} | 1.052 | 1.004–1.086 | 0.018 |

Egger regression (bias estimate) | −0.014 | — | 0.08 | −0.018 | — | 0.10 |

Heterogeneity (Cochran Q) | — | — | 0.2 | — | — | 0.59 |

*ORs are given in units of fold increase in type 2 diabetes risk per unit increase in mmHg, except the unweighted score, which is given in unit increase per allele.

†95% CI from normal distribution.

‡

*P*value from χ^{2}test.§95% CI calculated by bootstrapping.

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*P*value from Student*t*test.