Table 1

Summary statistics for genetic instruments used for causal inference analysis for SBP to type 2 diabetes

Expanded set (n = 28)Conservative set (n = 13)
OR*95% CIPOR*95% CIP
Cumulative GRS1.0181.009–1.0289.1 × 10−51.0211.008–1.0331.5 × 10−3
Unweighted GRS1.0081.003–1.0132.0 × 10−31.0081.001–1.0150.018
Weighted-median GRS§1.0181.006–1.033< 0.051.0201.003–1.039< 0.05
Egger regression (causal estimate)§||1.0431.006–1.0645.5 × 10−31.0521.004–1.0860.018
Egger regression (bias estimate)−0.0140.08−0.0180.10
Heterogeneity (Cochran Q)0.20.59
  • *ORs are given in units of fold increase in type 2 diabetes risk per unit increase in mmHg, except the unweighted score, which is given in unit increase per allele.

  • †95% CI from normal distribution.

  • P value from χ2 test.

  • §95% CI calculated by bootstrapping.

  • ||P value from Student t test.