Table 2

Metabolic parameters in normal wild-type mice

ParameterYFPAd5E4ORF1 lowAd5E4ORF1 highAd36E4ORF1 lowAd36E4ORF1 high
Serum glucose (mg/dL)226.5 ± 18.8193.1 ± 12.3210.1 ± 8.3201.4 ± 8.6146.6 ± 20.5**
Serum insulin (ng/mL)0.71 ± 0.350.61 ± 0.150.53 ± 0.140.65 ± 0.170.29 ± 0.08
Serum cholesterol (mg/dL)76.3 ± 6.790.5 ± 11.080.3 ± 7.898.6 ± 9.673.7 ± 11.0
Serum triglycerides (mg/dL)75.6 ± 11.654.6 ± 5.674.6 ± 8.961.0 ± 4.2137.9 ± 14.7**
Serum NEFA (mEQ/L)0.41 ± 0.040.50 ± 0.040.48 ± 0.050.54 ± 0.120.80 ± 0.08
Serum leptin (ng/mL)1.20 ± 0.291.73 ± 0.251.39 ± 0.351.95 ± 0.341.22 ± 0.38
Liver cholesterol (mg/g)0.91 ± 0.070.96 ± 0.101.04 ± 0.150.74 ± 0.071.16 ± 0.25
Liver triglyceride (mg/g)1.01 ± 0.111.30 ± 0.241.51 ± 0.211.74 ± 0.264.68 ± 0.82**
Liver NEFA (mEQ/g)0.017 ± 0.0020.014 ± 0.0010.035 ± 0.002*0.012 ± 0.0010.041 ± 0.003**
Liver glycogen (mg/g)83.8 ± 3.270.4 ± 5.475.7 ± 5.174.5 ± 3.151.1 ± 3.6**
  • Data are mean ± SEM. Low, 2 × 109 vg/mouse; high, 2 × 1010 vg/mouse. n = 5/group. NEFA, nonesterified fatty acid.

  • *P < 0.05,

  • **P < 0.01 vs. YFP.