Table 1

Metabolic parameters in db/db mice and DIO mice

db/db miceDIO mice
ParameterControlAd5E4ORF1Ad36E4ORF1ControlAd5E4ORF1Ad36E4ORF1
Serum glucose (mg/dL)470 ± 61.2424 ± 51.6292 ± 32.4*225.9 ± 16.0182.3 ± 11.3*172.8 ± 14.8*
Serum insulin (ng/mL)17.7 ± 4.25.0 ± 1.4*5.5 ± 2.1*1.73 ± 0.221.01 ± 0.280.37 ± 0.21***
Serum cholesterol (mg/dL)80.5 ± 9.483.2 ± 8.4106.4 ± 9.8176.9 ± 18.3139.6 ± 12.2168.4 ± 15.5
Serum triglycerides (mg/dL)159.1 ± 36.9102.8 ± 9.479.0 ± 9.499.8 ± 9.492.7 ± 10.359.7 ± 7.3**
Serum NEFA (mEQ/L)0.45 ± 0.050.44 ± 0.060.41 ± 0.030.36 ± 0.030.31 ± 0.040.30 ± 0.04
Serum leptin (ng/mL)49.3 ± 4.343.8 ± 4.351.2 ± 5.620.0 ± 1.014.2 ± 1.4**3.8 ± 1.0***
Serum adiponectin (μg/mL)6.4 ± 0.65.4 ± 0.54.4 ± 0.4*12.0 ± 0.610.4 ± 0.48.2 ± 0.6***
Liver cholesterol (mg/g)10.3 ± 1.313.5 ± 1.113.3 ± 1.015.6 ± 3.014.8 ± 3.116.1 ± 2.4
Liver triglycerides (mg/g)149.1 ± 9.4173.4 ± 9.4186.6 ± 9.4113.9 ± 38.5136.8 ± 39.3262.5 ± 21.8**
Liver NEFA (mEQ/g)0.24 ± 0.020.20 ± 0.010.21 ± 0.30.16 ± 0.010.16 ± 0.010.15 ± 0.01
Liver glycogen (mg/g)7.49 ± 0.735.94 ± 0.156.20 ± 0.285.40 ± 0.384.54 ± 0.342.86 ± 0.10**
  • Data are mean ± SEM. n = 8 per group in db/db experiment. n = 8 control, 8 Ad5E4ORF1, and 9 Ad36E4ORF1 in DIO experiment. NEFA, nonesterified fatty acid.

  • *P < 0.05,

  • **P < 0.01,

  • ***P < 0.001 vs. control.