Table 3

Total of 1 × 107 NOD.Rag1null.AI4 splenocytes fail to transfer diabetes into irradiated NOD.IFN-γRnull recipients, but induce disease in NOD and NOD.IFN-γnull recipients

Recipient*Fraction diabeticPercent diabeticχ2P value
Experiment 1Experiment 2
NOD2/44/5670.2125
NOD.IFN-γnull4/43/3100
NOD.IFN-γRnull0/40/400.0002
  • *Recipients were monitored for 15 days after adoptive transfer of AI4 splenocytes.

  • P values from χ2 analyses comparing the frequency of AI4 splenocyte–induced T1D between NOD.IFN-γnull and NOD and NOD.IFN-γRnull.