Table 2

Total of 1 × 107 NOD.Rag1null.AI4 splenocytes fail to transfer T1D into unmanipulated genetically modified stocks of NOD mice that lack T cells or B cells, but they efficiently induce disease in NOD.Rag1null mice lacking both cell types

Recipient*Fraction diabeticPercent diabeticχ2P value
NOD.IFN-γnull5/5100
NOD0/50<0.01
NOD.IgHnull0/50<0.01
NOD.TCRαnull0/50<0.01
NOD.CD8null0/60<0.001
NOD.Rag1null7/7100NS
  • *Recipients were monitored for diabetes development for 10 weeks after adoptive transfer of AI4 splenocytes.

  • P values from χ2 analyses comparing the frequency of AI4 T cell–induced T1D between NOD.IFN-γnull mice and NOD, NOD.IgHnull, NOD.TCRαnull, NOD.CD8null, and NOD.Rag1null stocks.