Table 2

Rare NPC1 variants identified in young obese subjects in comparison with lean control subjects

N total (male)Age (years)BMI (kg/m2)Rare NPC1 variant
Mean (SD)RangeMean (SD)RangeN (%)OR (95% CI)P value
Stage 1
 Obese patients244 (104)23.1 (6.2)13.0–35.036.7 (4.5)33.0–59.810 (4.10)4.0 (1.3–11.7)0.0075
 Control subjects468 (166)27.0 (4.2)18.0–35.019.6 (1.6)17.5–23.05 (1.07)
Stage 2
 Obese patients227 (98)20.9 (4.3)13.0–30.039.4 (4.2)35.1–61.76 (2.64)0.030
 Control subjects219 (92)20.9 (4.4)13.0–30.020.4 (1.5)17.6–23.00 (0)
Combined
 Obese patients471 (202)22.3 (5.4)13.0–35.038.0 (4.6)33.0–61.716 (3.40)4.8 (1.7–13.2)0.0008
 Control subjects687 (258)25.1 (5.0)13.0–35.019.8 (1.6)17.5–23.05 (0.73)