Table 2

GSIS of NPI grafts precultured for 48 h with and without MSCs

Cellular insulin (%)
Condition2.8 mmol/L20.0 mmol/LStimulation index
NPI alone0.60 ± 0.040.93 ± 0.121.50 ± 0.12
NPI + MSC0.83 ± 0.03*1.65 ± 0.06*2.01 ± 0.04*
  • Data are mean ± SEM of four independent experiments. In each experiment, NPIs were precultured for 48 h in the absence (NPI alone) or presence of 106 human bone marrow–derived MSCs (NPI + MSC). Stimulation indices were calculated by dividing the amount of insulin released at high glucose (20.0 mmol/L) by that released at low glucose (2.8 mmol/L).

  • *P < 0.01.