Table 3

Summary of reports on generating β-like cells: other notable features

Report, year (ref.)Other notable features
Rezania et al., 2014 (5)Insulin granules, cytosolic calcium flux, reduced C-peptide after insulin injection in vivo
Pagliuca et al., 2014 (6)Insulin granules, cytosolic calcium flux, multiple sequential responses to glucose in vitro, global gene expression
Russ et al., 2015 (8)Insulin granules
Zhu et al., 2016 (10)Expansion of early progenitors
Vegas et al., 2016 (7)Diabetes reversal in immunocompetent mouse with encapsulation, multiple sequential responses to glucose in vitro
Millman et al., 2016 (9): T1D iPSCInsulin granules, multiple sequential responses to glucose in vitro, global gene expression
Millman et al., 2016 (9): ND iPSCInsulin granules, multiple sequential responses to glucose in vitro, global gene expression
  • iPSC, induced pluripotent stem cells.